During the early stages of Spanish colonization in the Americas, the Spanish monarchy established various policies and systems to manage their new territories and indigenous populations. One pivotal system implemented was the encomienda system, which granted Spanish settlers the right to extract labor from Indigenous peoples in exchange for supposed protection and religious instruction.
While this system was intended to benefit both the Spanish and the indigenous populations, it often resulted in severe exploitation and demographic declines among Native American communities. As colonial ambitions grew, the Spanish also established missions, presidios, and other forms of governance, consolidating their control over vast regions.
Considering these practices, which aspect of Spanish colonization had the most significant and lasting impact on indigenous life and social structures by the mid-17th century?