Biochemical Interactions in Peptide Sequences

Very Hard Organic Chemistry Biomolecules

Consider a peptide sequence of 5 amino acids: Glycine (Gly), Alanine (Ala), Serine (Ser), Leucine (Leu), and Methionine (Met). This peptide undergoes a series of biochemical reactions in the body, including phosphorylation and the formation of disulfide bonds. The sequence can be represented as Gly-Ala-Ser-Leu-Met. In your study of biomolecules, you encounter the structural characteristics of amino acids and their reactivity under different conditions.

Which of the following statements accurately describes a biochemical process that could occur with this peptide in a cellular environment regarding the potential interactions between the amino acids involved?

Phosphorylation of the serine residue would enhance the overall hydrophilicity of the peptide.

Disulfide bonds can form between the glycine and methionine residues.

The primary structure can be altered by a deamidation reaction occurring on alanine.

Leucine's side chain can form ionic interactions with the hydroxyl group of serine.

Hint

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