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Medical College Admission Test
Biological and Biochemical Foundations of Living Systems

Consequences of Electron Transport Chain Inhibition on ATP Production

Very Hard Biochemistry Bioenergetics

In aerobic respiration, glucose is oxidized to produce ATP through a series of metabolic pathways. The complete oxidation of one glucose molecule in the presence of oxygen involves glycolysis, the citric acid cycle, and oxidative phosphorylation. Each of these processes contributes to the ATP yield, primarily through substrate-level phosphorylation and chemiosmosis.

Consider the role of proton gradients established during oxidative phosphorylation. These gradients are essential for ATP synthesis via ATP synthase. Assume a specific mitochondrial condition where the electron transport chain (ETC) is partially inhibited, leading to a diminished proton gradient.

Which of the following statements best describes the potential consequence of this inhibition on ATP production during aerobic respiration?

Hint

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