Considerations for Acetaminophen in Pain Management

A 65-year-old patient is admitted to the hospital with a diagnosis of osteoarthritis. The healthcare provider orders acetaminophen 500 mg orally every 6 hours as needed for pain management. The nurse knows that while acetaminophen is commonly used for pain, there are potential risks involved, especially with prolonged use.

Which of the following statements best describes a critical consideration the nurse should be aware of when administering this medication?