Effect of NADH on Pyruvate Dehydrogenase Complex

Very Hard Biochemistry Metabolism

In a cellular context, the pyruvate dehydrogenase complex (PDC) plays a crucial role in metabolic pathways, linking glycolysis to the Krebs cycle. This multienzyme complex catalyzes the conversion of pyruvate, generated from glycolysis, into acetyl-CoA while releasing CO2 and reducing NAD+ to NADH.

As a regulatory mechanism, the activity of the PDC is influenced by various metabolic signals. For instance, high levels of NADH, acetyl-CoA, or certain ratios of ADP to ATP could result in feedback inhibition of the PDC. Conversely, substrate availability and the need for ATP can stimulate its activity.

Considering these aspects, which of the following best describes the impact of elevated levels of NADH on the pyruvate dehydrogenase complex and the overall metabolic pathway?

Elevated NADH promotes the conversion of pyruvate to acetyl-CoA, increasing energy production.

Elevated NADH inhibits the pyruvate dehydrogenase complex, leading to decreased acetyl-CoA and energy production.

Elevated NADH has no effect on the pyruvate dehydrogenase complex, allowing continuous conversion of pyruvate.

Elevated NADH stimulates glycolysis, leading to more pyruvate production to overwhelm the complex.

Hint

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