European-Native American Relations in the Early 16th Century

During the period of European exploration and colonization in the Americas, there were many interactions between European settlers and Native American tribes. These interactions ranged from trade and cooperation to conflict and violence. Early 16th-century encounters led to significant changes for Native American societies, which were often unprepared for the cultural and ecological shifts introduced by European settlers. Based on these interactions, which of the following statements accurately reflects the nature of European-Native American relations during this time?