In cellular biology, the structure and function of various organelles are crucial for understanding how cells operate. One important organelle is the endoplasmic reticulum (ER), which plays a significant role in protein and lipid synthesis. The ER comes in two types: rough and smooth. The rough ER is studded with ribosomes, while the smooth ER lacks these ribosomes. These differences in structure correlate with their respective functions. Considering the functions of the rough and smooth endoplasmic reticulum, which of the following statements is most accurate?