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Medical College Admission Test
Biological and Biochemical Foundations of Living Systems

Impact of Inhibiting DNA Polymerase Epsilon

Very Hard Biochemistry Nucleic Acids And Dna Replication

Consider a eukaryotic cell undergoing DNA replication. During this process, several enzymes and proteins play critical roles in ensuring accurate and efficient synthesis of the new DNA strands. Imagine a scenario where a specific inhibitor targets DNA polymerase epsilon, which is responsible for leading strand synthesis. How would this selective inhibition affect the overall process of DNA replication, particularly in relation to the coordination between the leading and lagging strands?

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