Hormonal Feedback in the HPA Axis

In the context of the endocrine system, various hormones play crucial roles in metabolic regulation and physiological responses to stress. Consider the feedback mechanism of the hypothalamic-pituitary-adrenal (HPA) axis and its significant hormones: corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol. Each hormone has specific effects on the body, particularly in response to stress.

Among the hormones involved in the HPA axis, which hormone is chiefly responsible for primarily inhibiting the release of corticotropin-releasing hormone (CRH) from the hypothalamus?