Impact of Enhancer Mutation on Gene Expression

In the context of molecular biology, the regulation of gene expression is influenced by various mechanisms, including the role of enhancers and silencers. Enhancers are regulatory DNA sequences that can increase the likelihood of transcription of particular genes, while silencers can suppress transcription. In eukaryotic cells, the spatial organization of chromatin can impact how transcription factors interact with these elements. A specific type of enhancer is known as a locus control region (LCR), which can enhance transcription of linked genes in a locus. Consider the following scenario regarding a genetic regulatory protein's interaction with an enhancer in a defined cell type:

A mutation occurs in the DNA sequence of an enhancer, resulting in a change in the binding affinity of transcription factors. What is the most likely outcome of this mutation in relation to gene expression?