Impact of Enzyme Activity on Cellular Bioenergetics

Very Hard Biochemistry Bioenergetics

A metabolic pathway is being studied in a laboratory setting where researchers have identified a new enzyme that catalyzes a critical step in the conversion of glucose to pyruvate during glycolysis. This enzyme utilizes fructose-2,6-bisphosphate as an allosteric activator, considerably enhancing the rate of reaction under various concentrations of glucose and ATP. The researchers hypothesize that this pathway may have altered bioenergetic efficiency in response to cellular stress.

Which of the following statements accurately describes how alterations in the action of this enzyme could influence the overall bioenergetics within the cell, particularly regarding ATP production?

Increased activity of this enzyme will lead to higher production of NADH, enhancing oxidative phosphorylation.

Reduced activity of this enzyme will decrease the overall rate of glycolysis, resulting in lower ATP yield from substrate-level phosphorylation.

The enzyme's activation by fructose-2,6-bisphosphate signifies that the cell is in a high-energy state, which would inhibit glycolysis to prevent unnecessary ATP production.

Increased production of this enzyme will preferentially direct pyruvate toward gluconeogenesis, decreasing acetyl-CoA availability.

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