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Medical College Admission Test
Biological and Biochemical Foundations of Living Systems

Impact of Enzyme Activity on Glycolysis

Very Hard Biochemistry Metabolism

During cellular respiration, glucose undergoes a series of biochemical transformations where its energy is gradually released and captured in the form of ATP. These reactions can occur aerobically or anaerobically depending on the availability of oxygen. Specifically, the glycolytic pathway plays a crucial role in the initial breakdown of glucose into pyruvate, yielding a net gain of 2 ATP molecules. Diagramming this process, one can describe how the phosphorylated intermediates help in trapping the glucose within the cell and facilitating its subsequent breakdown.

Consider the following additions to the glycolytic pathway: an increase in enzyme X activity, which catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, and an increase in the concentration of pyruvate. Based on these changes, which statement accurately summarizes the impact on the flow of metabolites in the glycolytic pathway?

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