Impact of Histone Acetylation on Gene Expression

Recent studies have revealed important details about the regulation of gene expression in eukaryotic cells. One such mechanism involves the interaction of transcription factors with specific DNA sequences proximal to the promoter region of a gene. These transcription factors can either activate or repress transcription. In addition, epigenetic modifications such as DNA methylation and histone acetylation are known to play significant roles in the accessibility of chromatin for transcriptional machinery.

Considering the various interactions and modifications, which of the following statements best describes a consequence of increased histone acetylation at the promoter region of a gene?