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Medical College Admission Test
Chemical and Physical Foundations of Biological Systems

Inhibition of Glycolysis by ATP

Very Hard Biochemistry Metabolism

During cellular respiration, the metabolic pathway of glycolysis plays a crucial role in converting glucose into pyruvate, generating ATP and NADH in the process. One of the key regulatory steps in glycolysis is the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, catalyzed by the enzyme phosphofructokinase-1 (PFK-1). This step is known to be allosterically regulated by various metabolites. In a scenario where a cell is under high energy demand, which of the following molecules is most likely to inhibit the activity of PFK-1 and thus slow down glycolysis?

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