Inhibition of Phosphofructokinase-1 in Glycolysis

In the human metabolic pathway, the conversion of glucose to pyruvate, which occurs through glycolysis, is a crucial step in energy production. One of the key regulatory enzymes in this pathway is phosphofructokinase-1 (PFK-1). This enzyme catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, utilizing ATP in the process. Factors influencing the activity of PFK-1 determine the overall rate of glycolysis and, consequently, glucose metabolism.

Considering the metabolic regulation of PFK-1, which of the following compounds is known to act as a potent inhibitor of this enzyme under typical physiological conditions?