During prenatal development, various stages are crucial for normal growth and brain development. Disruptions in these processes can lead to significant developmental disorders. Various teratogens can affect development through different mechanisms. For example, certain substances may lead to cognitive impairments or physical abnormalities based on the timing of exposure. One significant factor is the vulnerability of specific systems during the embryonic period. Based on your knowledge of these processes, which teratogen is most notable for its specific timing-related effects on cognitive development when exposure occurs during the first trimester of pregnancy?