Key Features of Transcription Factors in Gene Regulation

In molecular biology, the mechanisms influencing gene expression are highly complex and critical for cellular function. Transcription factors are proteins that bind to specific DNA sequences, modulating the transcription of nearby genes either by facilitating or blocking the recruitment of RNA polymerase. An important category of these factors includes enhancers and silencers, which can be located far from the actual gene they regulate. Recent studies have revealed that chromatin structure and the three-dimensional organization of the genome also play pivotal roles in the accessibility of transcription machinery to DNA. Understanding the interactions between transcription factors, DNA sequences, and chromatin is crucial for deciphering gene regulation in both normal biological processes and disease states. Given these complexities, which statement best describes one key feature of transcription factors involved in gene regulation?