In cellular metabolism, reactions often interconnect, allowing substrates and products to participate in multiple pathways. One such pathway is the citric acid cycle, also known as the Krebs cycle, which plays a crucial role in energy production through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. Each turn of the Krebs cycle generates high-energy molecules in the form of NADH and FADH2, which subsequently enter the electron transport chain to produce ATP.
Consider the following metabolic substrate: alpha-ketoglutarate. This intermediate is known to participate in the Krebs cycle. Which of the following statements accurately describes a direct metabolic fate of alpha-ketoglutarate during the cycle?