Michaelis-Menten Kinetics and Enzyme Saturation

Hard Biochemistry Amino Acids And Proteins

In the context of enzyme kinetics, consider the Michaelis-Menten model, which describes the rate of enzymatic reactions. An important aspect of this model is the effect of substrate concentration on the reaction rate. If the substrate concentration is much greater than the Michaelis constant (K_m), the reaction rate approaches a maximum rate (V_max).

Given this information, which of the following statements about amino acids or enzymes in relation to the Michaelis-Menten kinetics is TRUE?

Enzymes can only catalyze reactions that require amino acids as substrates.

The turnover number (k<sub>cat</sub>) of an enzyme increases as substrate concentration decreases.

When substrate concentration is far above K<sub>m</sub>, the reaction rate will show a first-order dependence on substrate concentration.

At high substrate concentrations, diminishing returns occur due to enzyme saturation.

Hint

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