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Medical College Admission Test
Chemical and Physical Foundations of Biological Systems

Nucleophilic Addition of Acetophenone

Medium Organic Chemistry Carbonyl Chemistry

The carbonyl group, C=O, plays a significant role in organic chemistry and is found in a variety of functional groups such as aldehydes, ketones, carboxylic acids, esters, and amides. The reactivity of carbonyl compounds often depends on the surrounding groups and the specific reactivity patterns associated with them.

Consider the following carbonyl compound:

Acetophenone (C8H8O), which has both a methyl group and a carbonyl group. When subjected to nucleophilic attack, the carbonyl carbon is a site of significant electrophilic character.

Which of the following reagents could be used to efficiently convert acetophenone into its corresponding alcohol via nucleophilic addition?

Hint

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