Pathophysiological Mechanisms of Systemic Lupus Erythematosus

Very Hard Physiological Adaptation Pathophysiology

A 54-year-old female patient is diagnosed with systemic lupus erythematosus (SLE), an autoimmune disorder characterized by chronic inflammation and damage to various body systems. The nurse is reviewing the pathophysiology of SLE to provide education to the patient. SLE can affect multiple organs and systems, leading to a variety of clinical manifestations.

The nurse needs to identify physiological mechanisms involved in the pathophysiology of systemic lupus erythematosus that could lead to worsened organ function. Which of the following pathophysiological processes are associated with SLE? Select all that apply.

Select all that apply:

Autoantibody production leading to immune complex formation.

Increased levels of circulating cytokines and inflammation.

Reduction in complement system activity.

Formation of vasculitis affecting blood flow to organs.

Alteration in T and B lymphocyte function.

Damage to renal tubules resulting from immune-mediated processes.

Hint

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