Point Mutation Effect on Hydrogen Bonding in Peptides

Consider a scenario where a peptide consisting of five amino acids is analyzed. The amino acids in this peptide are serine (Ser), threonine (Thr), alanine (Ala), cysteine (Cys), and aspartic acid (Asp). You are tasked with identifying a point mutation that would result in the loss of a functional characteristic of the peptide. Which of the following substitutions would most likely disrupt the hydrogen bonding capacity of this peptide?