Potential Adverse Effect of NSAIDs in Renal Dysfunction

A patient with a history of renal dysfunction is prescribed a non-steroidal anti-inflammatory drug (NSAID) for pain management. As the nurse, it is essential to understand that NSAIDs can lead to several adverse effects.

Fill in the blank: One of the most serious potential side effects of NSAID use in patients with compromised kidney function is __________, which can lead to fluid retention and worsening of renal function.