Regulation of Phosphofructokinase in Glycolysis

During cellular respiration, the conversion of glucose to pyruvate is a critical step that occurs in the cytoplasm through the process of glycolysis. The initial stages of this metabolic pathway involve various enzymes and co-factors that facilitate the reactions required for breaking down glucose. This pathway not only produces energy in the form of ATP but also generates reducing equivalents in the form of NADH.

In particular, one of the key regulatory enzymes in glycolysis is phosphofructokinase-1 (PFK-1), which is influenced by several metabolic signals. Understanding the regulation of PFK-1 is crucial for appreciating how glucose metabolism is adapted to meet cellular energy demands.

Given the importance of glucose metabolism in human physiology, alterations in this pathway can lead to various metabolic disorders, including diabetes mellitus. The activity of PFK-1 can be affected by factors such as ATP concentration, AMP levels, and the presence of fructose-2,6-bisphosphate, a potent activator of the enzyme.

Which of the following statements accurately describes the role of PFK-1 in glycolysis regulation?