Regulation of Pyruvate Dehydrogenase

Hard Biochemistry Metabolism

During cellular respiration, the metabolism of glucose involves several enzymatic pathways. One critical pathway is glycolysis, which occurs in the cytoplasm and converts glucose to pyruvate, yielding ATP and NADH. Following glycolysis, pyruvate enters the mitochondria and is converted to acetyl-CoA by the pyruvate dehydrogenase complex, a multienzyme complex requiring several cofactors. Pyruvate dehydrogenase itself is subject to regulation by various metabolites and modifications.

In the context of cellular energy metabolism, which of the following statements regarding the function and regulation of pyruvate dehydrogenase is TRUE?

Pyruvate dehydrogenase is activated by high levels of acetyl-CoA.

Increased levels of NADH inhibit the activity of pyruvate dehydrogenase.

The enzyme converts acetyl-CoA into pyruvate as a part of gluconeogenesis.

Pyruvate dehydrogenase requires biotin as a cofactor for its activity.

Hint

Submitted10.1K

Correct8.3K

% Correct82%