Regulatory Enzyme Inhibition in Glycolysis

During the catabolism of carbohydrates, various pathways are utilized to break down glucose into usable energy. One of the key regulatory enzymes in glycolysis is phosphofructokinase-1 (PFK-1), which is influenced by various metabolites. This enzyme catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. The activity of PFK-1 is crucial in determining the flow of carbon through glycolysis.

Which of the following metabolites acts as an allosteric inhibitor of phosphofructokinase-1?