Role of DNA Polymerase in Replication

Hard Biochemistry Nucleic Acids And Dna Replication

During DNA replication, the process is not as straightforward as merely unwinding and copying the DNA strands. Various enzymes play crucial roles in ensuring the accuracy and efficiency of replication. One key enzyme involved in this process is DNA polymerase. It adds nucleotides to a growing DNA strand during replication, but this action is only possible under specific conditions. Understanding the requirements for nucleotide addition by DNA polymerase is essential for comprehending how DNA replication occurs accurately.

Consider the enzyme's requirements: DNA polymerase can only add nucleotides to an existing strand of DNA. This means that some form of primer or existing strand must be present. This knowledge is fundamental when considering possible mutations or replication errors.

Based on this information, which statement regarding DNA polymerase’s activity during replication is accurate?

DNA polymerase can initiate replication without a primer.

DNA polymerase can only add nucleotides to a single-stranded DNA template without a preceding primer.

DNA polymerase can only elongate a DNA strand from a preexisting primer or strand.

DNA polymerase functions effectively with ribonucleotides as primers.

Hint

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