Alexandra is a high-net-worth individual considering estate planning strategies to minimize taxes on her portfolio. She is particularly focused on optimizing her capital gains tax exposure as she plans to pass her investments to her children. After consulting with a tax advisor, she learns about various strategies, including tax-loss harvesting and gifting appreciated assets to her heirs during her lifetime.

As she analyzes her options, Alexandra is aware that the timing of asset sales and the method of transferring her wealth can significantly influence her family's tax liability. Given her current income level and her children’s financial circumstances, she needs to determine which of the presented strategies will be most effective in reducing her overall tax burden.

Based on her situation, what should Alexandra prioritize to minimize her tax liabilities while effectively transferring her wealth?