Interaction of Ghrelin and Leptin in Hunger Regulation

During a significant study on the physiological aspects of hunger and eating behaviors, researchers discovered a fascinating correlation between various hormones and appetite regulation. Key hormones identified in the study include ghrelin, which is responsible for stimulating appetite, and leptin, which signals fullness. Understanding the intricate balance of these hormones provides insights into how the brain, particularly the hypothalamus, orchestrates hunger and satiety.

Based on your knowledge of the physiological mechanisms involved in hunger and the role of neurotransmitters and hormones in appetite regulation, which of the following describes the interaction between ghrelin and leptin in relation to eating behavior?