Understanding Transcription Regulation in Eukaryotes

Hard Biology Molecular Biology

In a recent study, researchers explored the mechanisms of gene expression in eukaryotic cells. They examined the role of various regulatory sequences in the functioning of RNA polymerase II during transcription. The focus was on how transcription factors interact with promoter and enhancer regions to initiate transcription. The study found that mutations in these regulatory elements could lead to significant changes in gene expression levels.

Additionally, they discovered that chromatin remodeling complexes also play a critical role in facilitating access to DNA for transcriptional machinery. The researchers used various biochemical assays to quantitatively assess the binding affinity of transcription factors to their respective DNA regions.

Based on this information, which of the following statements about transcription regulation is correct?

Transcription factors can only bind to promoter regions, not enhancer regions.

Mutations in regulatory sequences exclusively prevent the binding of RNA polymerase II.

Chromatin remodeling complexes can facilitate transcription by altering DNA accessibility.

Transcription is initiated without the need for any regulatory sequences.

Hint

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